Flavivirus induces MHC antigen on human myoblasts: A model of autoimmune myositis?
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Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies.
In the human inflammatory myopathies (polymyositis and dermatomyositis), the early, widespread appearance of MHC class I on the surface of muscle cells and the occurrence of certain myositis-specific autoantibodies are striking features. We have used a controllable muscle-specific promoter system to up-regulate MHC class I in the skeletal muscles of young mice. These mice develop clinical, bioc...
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ژورنال
عنوان ژورنال: Muscle & Nerve
سال: 1992
ISSN: 0148-639X,1097-4598
DOI: 10.1002/mus.880151109